Beyond hematopoietic property; administration of erythropoietin for nephroprotection
نویسندگان
چکیده
منابع مشابه
The influence of the pleiotropic action of erythropoietin and its derivatives on nephroprotection
Erythropoietin (EPO) is traditionally described as a hematopoietic cytokine or growth hormone regulating proliferation, differentiation, and survival of erythroid progenitors. The use of EPO in patients with chronic kidney disease (CKD) was a milestone achievement in the treatment of anemia. However, EPO involves some degree of risk, which increases with increasing hemoglobin levels. A growing ...
متن کاملHuman hematopoietic progenitors express erythropoietin.
Erythropoietin (EPO) is a factor essential for erythroid cell proliferation, differentiation, and survival. The production of EPO by the kidneys in response to hypoxia and anemia is well documented. To determine whether EPO is also produced by hematopoietic cells, we analyzed the expression of EPO in normal human hematopoietic progenitors and in their progeny. Undifferentiated CD34(+)lin- hemat...
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Infiltration of inflammatory cells into adipose tissue causes insulin resistance in animal models and is associated with insulin resistance in humans (1,2). Among potential therapeutic approaches, the hormone erythropoietin (EPO) exerts anti-inflammatory effects in a variety of nonerythroid tissues (3), in which the receptor for EPO (EPO-R) is widely expressed (4). Various observations suggest ...
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This paper studies the problem of testing if an input (Γ, ◦), where Γ is a finite set of unknown size and ◦ is a binary operation over Γ given as an oracle, is close to a specified class of groups. Friedl et al. [Efficient testing of groups, STOC’05] have constructed an efficient tester using poly(log |Γ|) queries for the class of abelian groups. We focus in this paper on subclasses of abelian ...
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Erythropoietin (epo) is the primary regulator of the rate of red blood cell formation in mammals. Because it is formed in the kidney and acts on the bone marrow, its action is classically endocrine. We have shown by PCR that marrow cells contain epo mRNA and that antisense oligodeoxynucleotides, to both epo and its receptor, act on multipotent hematopoietic cells to cause a decrease in mixed er...
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ژورنال
عنوان ژورنال: Journal of Renal Injury Prevention
سال: 2017
ISSN: 2345-2781
DOI: 10.15171/jrip.2017.56